NF-κB pathway as a molecular target for curcumin in diabetes mellitus treatment: Focusing on oxidative stress and inflammation

This study explores the role of cellular and molecular elements, such as hyperglycemia-induced oxidative stress, endothelial dysfunction, and the involvement of the NF-κB pathway in inflammation and immune regulation in the onset of diabetes mellitus. It extensively investigates the potential therapeutic benefits of curcumin (CUR), a bioactive compound known for its antioxidant, anti-inflammatory, and hypoglycemic properties, in addressing diabetic complications, predominantly via the modulation of the NF-κB pathway. The study highlights the importance of the NF-κB pathway as a molecular target for CUR in the treatment of diabetes mellitus, focusing on oxidative stress and inflammation.